Arginine Alpha Ketoglutarate

Combined With Arginine Bring More Advantages To Body-builders and Athletes

Do Arginine Alpha Ketoglutarate and Arginine found in the Arkworld products enhance the athletes and body-builders performance and results?

You will have this question answered fully in this report.

Arkworld Athletes Article and Scientific  Research

By Chief Executive Scientist Jeff Golini

Looking into the benefits of Arginine Alpha-Ketoglutarate and Arginine, found in Arkworld Products in Scientific Literature

There are several scientific research articles that indicate the benefits of either arginine-alphaketoglutarate or alpha-ketoglutarate alone in athletic performance. The following is just a sampling of some of the more recent articles

1). Arginine alpha ketoglutarate, Creatine, amino acids, and medium-
     chain triglycerides on endurance and performance.

College of Kinesiology, University of Saskatchewan, Saskatoon, SK, Canada.

Arginine Alpha Ketoglutarate (A-AKG) found in Arkworlds Ark 1 product is a precursor for nitric oxide production and has the potential to improve blood flow and nutrient delivery to the muscles, which in turn helps to increase muscle mass, strength and power from supplementations such as Creatine.

This study compared a dietary supplement of Creatine, Glutamine, Taurine, branched-chain amino acids and medium-chain triglycerides with Arginine Alpha Ketoglutarate and one without, on exercise performance and body composition.

Thirty-five men (approximately 23 years of age) were randomized and studied in both situations for 10 days. Body composition, muscle endurance (bench press), and peak and average power (Wingate tests) were measured before and after supplementation.

-Bench-press repetitions over 3 sets were increased significantly using Arginine Alpha-Ketoglutarate along with Creatine as opposed to using Creatine by itself.

-Peak power and average power was also significantly increased over the time by including Arginine Alpha Ketoglutarate in the studies.

-The group of men combining Arginine Alpha-Ketoglutarate (A-AKG) with the other ingredients such as Creatine in the dietary supplement also had a greater increase in total body mass opposed to those men that were not taking Arginine Alpha-Ketoglutarate, with no significant changes in lean-tissue or fat mass.

These results suggest that using Arginine Alpha Ketogluterate found in Arkworlds Ark 1 supplement in combination with Creatine improves upper body muscle endurance and improves peak power output on repeated Wingate tests at a much greater level than using Creatine or other supplements by themselves. Interesting and Incredible results!

The combination of Arginine and Arginine Alpha Ketoglutarate with Micro Nutrition is a special formulation that is exclusive to Arkworld that also has the ability to increase the cellular healing and delivery mechanism within the body, which can add even greater to the results that an athlete may experience.

2). Pharmacokinetics, safety, and effects on exercise performance of L-arginine alpha-ketoglutarate in trained adult men.

Exercise and Sport Nutrition Laboratory at the Center for Exercise, Nutrition, and Preventative Health Research, Department of Health, Human Performance, and Recreation, Baylor University, Waco, Texas, USA.

OBJECTIVE:
We evaluated the pharmacokinetics, safety and efficacy of L-arginine Alpha Ketoglutarate (A-AKG) found in Arkworld Products, in trained adult men.

METHODS:
Subjects participated in two studies that employed a randomized, double-blind, controlled design.

In study 1:

Ten healthy men (30-50 years of age) fasted for 8 hours and then ingested 4 grams of time-released or non-timed-released Arginine Alpha Ketoglutamate( A-AKG). Blood samples were taken for 8 hours after A-AKG ingestion to assess the pharmacokinetic profile of L-arginine. After 1 week the alternative supplement was ingested.

In study 2:

In a placebo controlled study, 35 resistance-trained adult men (30-50 years of age) were randomly assigned to ingest 4 grams of Arginine Alpha Ketoglutarate three times a day for a total of 12 grams daily. Participants performed 4 days of periodized resistance training per week for
8 weeks.

At the beginning of the study, at the 4th week and at the 8th week of supplementation the following tests were performed: clinical blood markers, one repetition maximum bench press, isokinetic quadriceps muscle endurance, anaerobic power, aerobic capacity, total body water, body composition, and psychometric parameters tests. Data were analyzed by repeated measures
analysis of variance.

RESULTS:
In study 1: Significant differences were observed in plasma Arginine levels in subjects taking non-timed-release and timed-release Arginine Alpha-Ketogluterate.

In study 2: Significant differences were observed in the A-AKG group for bench press, Wingate peak power, blood glucose, and plasma Arginine.

CONCLUSION:
Arginine Alpha-Ketogluterate (A-AKG) found in Arkworld's Ark 1 supplementation appeared to be safe and well tolerated, and positively influenced the bench press and Wingate peak power performance.

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3). Ornithine alpha-ketoglutarate as a potent precursor of Arginine and Nitric Oxide: a new job for an old friend.

Biochemistry Laboratory, Htel-Dieu Hospital-AP-HP and Laboratory of Biological Nutrition EA 2498, School of Pharmacy, Paris 5 University.

Ornithine Alpha-Ketoglutarate (OKG) also used in the formulation process of Arkworld products is a salt formed of 2 molecules of Ornithine and 1 part Alpha-Ketoglutarate.

Its administration improves nutritional status in the chronically malnourished, for example in the elderly and acutely malnourished patients (especially burn and trauma patients). There is evidence that OKG activity is not the simple addition of the effects of Ornithine and Alpha-Ketoglutarate because the presence of both moieties is required to induce the generation of key metabolites such as glutamine, proline, and arginine, whereas this does not occur when one or the other is given separately.

This observation is related to the fact that the main feature of Ornithine at the whole-body level is to be metabolized through the Ornithine aminotransferase-dependent pathway, whereas the simultaneous administration of Ornithine and Alpha-Ketoglutamate saturates this pathway, diverting Ornithine towards metabolism into Arginine which is found in Arkworld's Ark 1.

For years, OKG activity has been associated with its ability to induce the secretion of anabolic hormones, such as insulin and Human Growth Hormone, and to increase glutamine and polyamine synthesis. Recent studies using chemical inhibitors of Nitric Oxide Synthase (NOS) suggest that nitric oxide derived from Arginine is involved in OKG activity.

In conclusion, this activity of Arginine Derived Nitric Oxide that can be produced from the Arginine and Arginine Alpha Ketogluterate found in Arkworld products is therefore highly effective as a supplement for athletes.

The increase of the anabolic hormones such as insulin and human growth hormone produced from taking Arginine and A-AKG not only increases training performance in athletes, but can help to increase blood flow, muscle mass, the post training healing process and recuperation along with endurance and performance increase, along with its Anti-Aging properties as well.

Something that all athletes need and look for!

4). Pharmacokinetics of Arginine and related amino acids found in
Arkworld products.

Clinical Chemistry Laboratory, Htel-Dieu Hospital, and Laboratory of Biological Nutrition EA 2498, Faculty of Pharmacy, University Paris 5 Ren Descartes, Paris 75006, France.

Arginine (ARG) and its related amino acids (AAs) Ornithine (ORN) and Citrulline (CIT) find a range of applications as dietary supplements in subgroups of healthy subjects (e.g., bodybuilders) and patients with acute or chronic malnutrition. These AAs appear to be well utilized in humans with, in
general, a rapid return of blood concentrations to basal values and low absolute and relative excretion in urine.

Based on published data for the maximum observed plasma concentrations (Cmax) after administration of doses in the range 5 to 10 grams, CIT (found in Arkworlds Ark 1) was shown to present relatively better absorption andsystemic bioavailability than ARG or ORN and add to the
absorption process greatly.

Comparison of these studies further indicates that CIT has higher bioavailability than ORN. The pharmacokinetics and metabolism of these AAs are modified by the coadministration of a salt such as Alpha-Ketoglutarate that modifies AA metabolism, as has clearly been demonstrated for ornithine alpha-ketoglutarate. Concomitant administration of a meal leads to a 15-to 30-min delay in Cmax. Finally, data from various pharmacokinetic studies together with basic physiology and biochemistry indicate that ARG is a net urea producer and ORN has a nitrogen-sparing effect, whereas CIT is neutral.


In conclusion, athletes, bodybuilders and sports people are always looking for increased performance and for better results from their chosen field. Using Arginine and Arginine Alpha Ketogluterate combined with Micro Nutrition found in the exclusive Arkworld products, as we have shown can significally increase that performance and results that they are looking for.

As the sports and athletic world continue to find more advanced ways to succeed to a greater extent and increase their overall performance and results, one thing is for sure; the revolutionary discoveries to date that are behind the Arkworld's products make them an incredible addition to any athlete's training program and a must to stay ahead of the competition!


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